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Newborn screening by MS/MS

Extended Newborn screening using MS/MS methodology

A partnership between ZenTech and RECIPE

ZenTech has developed Elisa reagents and offers comprehensive solutions for the Newborn Screening labs including preanalytics (collection filter paper, punchers) and analytics using automation through several partnerships.

• RECIPE, a leading company in LC MS/MS located in Germany has developed several products available for Dried Blood Spot (DBS) and dedicated to the Newborn Screening. The partnership with RECIPE in Newborn Screening represents an important milestone that will allow ZenTech to strengthen its position at a global level and to increase its offer with high quality and complementary products.

SCREENING ASSAYS using Dried Blood Spots on MS/MS

  • TARGETED MS/MS PKU-MSUD

    Code : J-KU-960
    Intended use : Targeted detection of Phe, Tyr, Leu, Val for screening of PKU and MSUD
    Method : MS/MS
    Sample size : Dried blood spot 3 mm
    Pre-analytical preparation :  ± 45 min
    Analysis time :  1.7 min / sample
    Analyte detected :  4
    Controls included :  Internal Standard provided
    test/kit : 960
    info : Request info
    The targeted PKU-MSUD MS/MS screening assay is an analytical sample processing assay specifically designed for the semi-quantification dosage of 4 amino acids (Phenylalanine, Tyrosine, Leucine and Valine) in neonates using blood spot samples on 903® filter collection paper.
    The entire sample preparation is performed with 96-well plates.

     

  • ClinSpot AA + Acylcarnitine Derivatized

    code :

    A-FC-001 : Without filter plates

    A-FC-002 : With filter plates

    Intended use : Determination of amino acids and acylcarnitines concentrations for newborn screening under derivatized conditions
    method : MS/MS
    sample size : Dried blood spot 3 mm
    Pre-analytical preparation : ± 1h45
    Analysis time :  1.6 min / sample
    Analyte detected :  47
    Controls included : Internal Standard provided
    test/kit : 960
    info : Request info
    The ClinSpot® Complete Kit provides reliable screening by determination of the amino acids and acylcarnitines concentrations. The entire sample preparation is performed with 96-well plates, alternatively also in combination with filters plates in order to ensure a high sample throughput.
  • ClinSpot AA + Acylcarnitine Non-Derivatized

    code :

    A-FC-003 : Without filter plates

    A-FC-004 : With filter plates

    intended use : Determination of amino acids and acylcarnitines concentrations for newborn screening under non-derivatized conditions
    method : MS/MS
    sample size : Dried blood spot 3 mm
    Pre-analytical preparation :  
    Analysis time :  
    Analyte detected :  
    Controls included :  
    test/kit : 960
    info : Request info

    This ClinSpot® Complete Kit, non-derivatized, stands out for its fast and easy sample preparation. Samples can be injected directly after an extraction step. The entire sample preparation is performed with 96-well plates alternatively also in combination with filter plates in order to ensure a high sample throughput

  • ClinMass Homocysteine in DBS

    code :

    A-FC-005

    Intended use : Reliable monitoring of total homocysteine
    method : MS/MS
    sample size : Dried blood spot 3 mm
    Pre-analytical preparation :  
    Analysis time :  1 min / sample
    Analyte detected :  
    Controls included :  
    test/kit : 960
    info : Request info

    The determination of Homocysteine in Dried Blood spots (DBS) is used for the Newborn Screening of inherited defects of the methionine metabolism (homocysteinuria). The ClinMass® Complete Kit allows a reliable determination of total homocysteine from filter spot specimen with a simple and quick sample preparation and an injection interval of 1.0 min only.