Reagents
NEONATAL MSUD Screening Assay is a quantitative enzymatic test that assays leucine, isoleucine and valine, often called the branched-chain amino acids (BCAAs), that accumulate in maple syrup urine disease (MSUD) also known as ketoacidemia.
This test is for maple syrup urine disease newborn screening, and is performed using dried blood samples on 903® or 226 type blotting paper.
Leucine, Isoleucine and Valine
In the first reaction of the NEONATAL MSUD Screening Assay, an enzyme, the leucine dehydrogenase, converts BCAAs in the sample to α-ketoisocaproate acid and NADH. Thereafter, the presence of NADH is quantified by colorimetry using tetrazolium salt. The results are read by measuring absorbance for which staining intensity will be proportional to the concentration of BCAAs in the sample.
The kit is intended for maple syrup urine disease newborn screening
Product code :
NEONATAL PKU Screening Assay is a quantitative enzyme assay used in phenylketonuria (PKU) newborn screening. It's a PKU test for newborns that quantifies an abnormal concentration of phenylalanine in dried blood samples on 903® or 226 blotting paper.
The Immunomat™ is intended for neonatal screening laboratories performing between 400 and 1000 daily determinations. With a maximum capacity of 7 microplates, it optimizes the rate of the laboratory by allowing the processing of different parameters in parallel.